Search results for "Drotrecogin alfa"

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High dose infusion of activated protein C (rhAPC) fails to improve neuronal damage and cognitive deficit after global cerebral ischemia in rats

2013

Abstract Purpose : Recent studies demonstrated anticoagulatory, antiinflammatory, antiapoptotic, and neuroprotective properties of activated protein C (APC) in rodent models of acute neurodegenerative diseases, suggesting APC as promising broad acting therapeutic agent. Unfortunately, continuous infusion of recombinant human APC (rhAPC) failed to improve brain damage following cardiac arrest in rats. The present study was designed to investigate the neuroprotective effect after global cerebral ischemia (GI) with an optimized infusion protocol. Methods : Rats were subjected to bilateral clip occlusion of the common carotid arteries (BCAO) and controlled hemorrhagic hypotension to 40 mmHg for…

IschemiaInflammationBrain damagePharmacologyNeuroprotectionBrain IschemiaRats Sprague-DawleyBrain ischemiamedicineAnimalsHumansCerebral perfusion pressureInfusions IntravenousCell Deathbusiness.industryGeneral NeuroscienceDrotrecogin alfaBrainmedicine.diseaseRecombinant ProteinsRatsAnesthesiamedicine.symptombusinessProtein CProtein Cmedicine.drugNeuroscience Letters

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PEPhysical Sciences and Engineering
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